药学前沿大讲堂第234讲——FXR, Bile Acids and Liver Diseases

时间: 
星期四, 2015/11/12 - 10:0012:00
地点: 
中山大学东校区药学院112会议室

报告人:Grace L. Guo,Rutgers University

主持人:毕惠嫦 副教授 ,中山大学药学院

  2015年11月12日(周四)上午10:00

  中山大学东校区药学院112会议室

 

报告人简介:

      Grace L. Guo (郭列军),美国新泽西州药学院药理和毒理糸终身制副教授。郭博士长期致力于核受体和信号传导对肝脏代谢的研究,包括FXR,PXR,CAR,FGF15/19和胆汁酸的调控。郭博士团队的研究包括组织特异性FXR调节胆汁酸生成,药物代谢和运输,脂肪肝,肝和大肠癌形成,和肝再生的转录调控。郭博士已发表了近78篇论文,文章被引用近三千次。郭博士长期参与论文审稿,美国及欧洲基金评审,及制药公司科研顾问。

      Associate Prof. Grace Liejun Guo is a tenured faculty in the Department of Pharmacology and Toxicology in the School of Pharmacy at the Rutgers University in New Jersey, USA. Dr. Guo has determined the roles of nuclear receptors and signaling pathways that are critical for liver homeostasis and metabolism, including farnesoid X receptor (FXR), pregnane X receptor, constitutive androstane receptor, fibroblast growth factor 15/19 and bile acids. The highlights of Dr. Guo’s research findings include understanding the cellular and molecular mechanism by which tissue-specific FXR functions to regulate bile acid homeostasis, transcriptional regulation of drug metabolism and transport, non-alcoholic hepatosteatosis, liver and colon carcinogenesis, and liver regeneration. Dr. Guo has published 78 peer-reviewed research and review articles on nuclear receptors and their regulation of liver and intestine functions. As the PI or Co-I on several NIH funding, Dr. Guo’s laboratory has laid the ground work by determining the role of intestinal FXR in regulating liver functions. Dr. Guo is a member of several scientific societies, scientific reviewer for the US and Italian NIH and private foundations, editorial board member and ad hoc manuscript reviewers for numerous prestigious journals, and invited speakers for national and international lectures and meetings.

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